SS-31 (ELAMIPRETIDE)
Compound Overview
SS-31, also known as Elamipretide, is a synthetic tetrapeptide belonging to the Szeto-Schiller (SS) family of mitochondria-targeting peptides. Its unique alternating aromatic and cationic amino acid sequence enables selective localization to the inner mitochondrial membrane, where it has been extensively investigated for its interactions with mitochondrial phospholipids, particularly cardiolipin. This distinctive targeting profile has made SS-31 an important investigational peptide for studying mitochondrial biology and cellular bioenergetics.
Researchers continue to investigate SS-31 in experimental models to better understand mitochondrial membrane dynamics, oxidative phosphorylation, ATP production, reactive oxygen species (ROS) regulation, and mitochondrial signaling pathways. The peptide has become a valuable research tool for exploring cellular energy metabolism, mitochondrial structure-function relationships, and peptide-mediated regulation of intracellular homeostasis.
As an investigational peptide, SS-31 supports laboratory research involving mitochondrial physiology, peptide pharmacology, molecular biology, and structure-activity relationships. Ongoing studies continue to examine its biochemical properties and mechanisms of action in controlled experimental settings.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | D-Arg-2',6'-DimethylTyr-Lys-Phe-NH2 (D-Arg-Dmt-Lys-Phe-NH2) |
| Molecular Formula | C32H49N9O5 |
| Molecular Weight | 639.79 g/mol |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| CAS Number | 736992-21-5 |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of SS-31 (ELAMIPRETIDE) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide stability. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Szeto HH. First-in-Class Cardiolipin-Protective Compound as a Therapeutic Agent to Restore Mitochondrial Bioenergetics. British Journal of Pharmacology.
- Birk AV, Chao WM, Bracken C, Warren JD, Szeto HH. Targeting Mitochondrial Cardiolipin and the Cytochrome c/Cardiolipin Complex to Promote Electron Transport and Optimize Mitochondrial ATP Synthesis. British Journal of Pharmacology.
- Zhao K, Luo G, Giannelli S, Szeto HH. Mitochondria-Targeted Peptide Prevents Mitochondrial Depolarization and Oxidative Damage. Journal of Biological Chemistry.
- Szeto HH, Schiller PW. Novel Therapies Targeting Inner Mitochondrial Membrane – From Discovery of SS Peptides to Elamipretide. Pharmacology & Therapeutics.
Compare with related compounds
Other compounds researchers commonly browse alongside SS-31 (ELAMIPRETIDE) in Longevity & Mitochondrial.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| SS-31 (ELAMIPRETIDE) | 99% | 639.79 g/mol | 736992-21-5 |
| EPITALON (EPITHALON) | 99% | 390.35 g/mol | 307297-39-8 |
| MOTS-c | 99% | 2,174.6 g/mol | 1627580-64-6 |
| NAD+ (NICOTINAMIDE ADENINE DINUCLEOTIDE) | 99% | 663.43 g/mol | 53-84-9 |
| HMG (HUMAN MENOPAUSAL GONADOTROPIN) | 99% | — | Not Applicable (Biological Gonadotropin Preparation) |
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