MOTS-c
Compound Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA region of mitochondrial DNA (mtDNA). Unlike most biologically active peptides encoded by the nuclear genome, MOTS-c originates from the mitochondrial genome, making it an important research target in the emerging field of mitochondrial signaling and mitochondrial-nuclear communication (mitonuclear signaling).
Researchers have extensively investigated MOTS-c for its role in cellular energy metabolism, metabolic homeostasis, stress adaptation, and mitochondrial signaling pathways. Experimental studies suggest that MOTS-c may influence intracellular metabolic regulation through interactions with pathways such as AMP-activated protein kinase (AMPK) and other nutrient-sensing mechanisms involved in cellular bioenergetics and metabolic adaptation.
As an investigational peptide, MOTS-c serves as a valuable laboratory tool for studying mitochondrial biology, cellular metabolism, endocrine physiology, molecular signaling, and structure-activity relationships. Ongoing research continues to explore its biochemical properties and mechanisms of action in controlled experimental models.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2,174.6 g/mol |
| CAS Number | 1627580-64-6 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of MOTS-c is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide stability and biological integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Lee C, Zeng J, Drew BG, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism.
- Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Adaptive Gene Expression in Response to Metabolic Stress. Cell Metabolism.
- Lee C. Mitochondrial-Derived Peptides in Metabolic Regulation and Healthy Aging. Experimental Gerontology.
- Merry TL, Ristow M. Mitochondrial Stress Signaling and Hormesis in Metabolic Regulation. Nature Reviews Endocrinology.
Compare with related compounds
Other compounds researchers commonly browse alongside MOTS-c in Longevity & Mitochondrial.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| MOTS-c | 99% | 2,174.6 g/mol | 1627580-64-6 |
| EPITALON (EPITHALON) | 99% | 390.35 g/mol | 307297-39-8 |
| SS-31 (ELAMIPRETIDE) | 99% | 639.79 g/mol | 736992-21-5 |
| NAD+ (NICOTINAMIDE ADENINE DINUCLEOTIDE) | 99% | 663.43 g/mol | 53-84-9 |
| HMG (HUMAN MENOPAUSAL GONADOTROPIN) | 99% | — | Not Applicable (Biological Gonadotropin Preparation) |
Need a Certificate of Analysis?
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