RETATRUTIDE
Compound Overview
Retatrutide is a synthetic 39-amino acid peptide engineered as a triple receptor agonist targeting the glucose-dependent insulinotropic polypeptide (GIP) receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucagon receptor (GCGR). The peptide has been designed to investigate the combined effects of incretin biology and glucagon receptor signaling within a single molecular entity. Owing to its multi-receptor pharmacology, Retatrutide has become an important investigational peptide in metabolic physiology, endocrinology, and peptide pharmacology research.
Researchers have studied Retatrutide in experimental models involving energy metabolism, glucose homeostasis, receptor pharmacology, appetite regulation, hepatic metabolism, and lipid biology. Its unique mechanism allows investigators to examine coordinated signaling across three distinct G protein-coupled receptors (GPCRs), providing valuable insight into integrated metabolic regulation and receptor interactions. Retatrutide remains an investigational peptide and has not been approved for general clinical use.
As an investigational peptide, Retatrutide supports laboratory research involving metabolic biology, endocrinology, molecular pharmacology, receptor signaling, and structure-activity relationship studies.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | 39-amino acid synthetic peptide (proprietary modified sequence) |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | Approximately 4,731.33 g/mol |
| CAS Number | 2381089-83-2 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of RETATRUTIDE is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Following reconstitution, avoid repeated freeze-thaw cycles, as these may reduce peptide stability and biological integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Coskun T, Urva S, Roell WC, et al. LY3437943, a Novel Triple GIP, GLP-1, and Glucagon Receptor Agonist for the Treatment of Metabolic Disease. Cell Metabolism.
- Jastreboff AM, Kaplan LM, Frías JP, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine.
- Müller TD, Finan B, Clemmensen C, et al. The New Biology and Pharmacology of Glucagon. Physiological Reviews.
- Campbell JE, Drucker DJ. Islet α Cells and Glucagon—Critical Regulators of Energy Homeostasis. Nature Reviews Endocrinology.
Compare with related compounds
Other compounds researchers commonly browse alongside RETATRUTIDE in Metabolic & Weight Research.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| RETATRUTIDE | 99% | Approximately 4,731.33 g/mol | 2381089-83-2 |
| AOD-9604 | 99% | 1,815.08 g/mol | 221231-10-3 |
| CAGRILINTIDE | 99% | Approximately 4,183.8 g/mol | 1415456-99-3 |
| MAZDUTIDE | 99% | Approximately 4.5 kDa | Not Assigned |
| SURVODUTIDE | 99% | Approximately 4.6 kDa | Not Assigned |
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