SURVODUTIDE
Compound Overview
Survodutide (formerly BI 456906) is a synthetic, long-acting investigational peptide developed as a dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Engineered using peptide sequence optimization and half-life extension technology, Survodutide has become an important research compound for investigating the coordinated effects of incretin and glucagon receptor signaling on metabolic physiology, energy homeostasis, and endocrine regulation.
Researchers have investigated Survodutide for its interactions with the GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR), enabling experimental evaluation of intracellular signaling pathways involved in glucose metabolism, lipid metabolism, mitochondrial function, and energy expenditure. Simultaneous activation of these receptor systems provides a valuable model for studying receptor cross-talk, peptide pharmacology, and mechanisms regulating whole-body metabolism.
As an investigational peptide, Survodutide supports laboratory research involving metabolic biology, endocrinology, receptor pharmacology, peptide engineering, and structure-activity relationship studies in controlled experimental settings.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Composition | Synthetic dual GLP-1 receptor and glucagon receptor agonist peptide |
| Molecular Weight | Approximately 4.6 kDa |
| CAS Number | Not Assigned |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of SURVODUTIDE is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide stability and biological integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Ambery P, et al. Survodutide (BI 456906), a Dual GLP-1/Glucagon Receptor Agonist: Phase 2 Evaluation in Adults with Overweight or Obesity. Nature Medicine.
- Tillner J, Posch MG, Wagner F, et al. A Novel Dual GLP-1/Glucagon Receptor Agonist for the Treatment of Metabolic Disorders: Pharmacokinetics and Pharmacodynamics. Clinical Pharmacology in Drug Development.
- Müller TD, Finan B, Clemmensen C, DiMarchi RD, Tschöp MH. The New Biology and Pharmacology of Glucagon. Physiological Reviews.
- Campbell JE, Drucker DJ. Islet α Cells and Glucagon—Critical Regulators of Energy Homeostasis. Nature Reviews Endocrinology.
Compare with related compounds
Other compounds researchers commonly browse alongside SURVODUTIDE in Metabolic & Weight Research.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| SURVODUTIDE | 99% | Approximately 4.6 kDa | Not Assigned |
| RETATRUTIDE | 99% | Approximately 4,731.33 g/mol | 2381089-83-2 |
| AOD-9604 | 99% | 1,815.08 g/mol | 221231-10-3 |
| CAGRILINTIDE | 99% | Approximately 4,183.8 g/mol | 1415456-99-3 |
| MAZDUTIDE | 99% | Approximately 4.5 kDa | Not Assigned |
Need a Certificate of Analysis?
Request COAs, HPLC, or MS documentation for SURVODUTIDE.