THYMOSIN ALPHA-1 (Tα1)
Compound Overview
Thymosin Alpha-1 (Tα1) is a synthetic 28-amino acid peptide corresponding to the naturally occurring thymic peptide first isolated from thymosin fraction 5. It is derived from the prothymosin alpha (PTMA) precursor protein and has been extensively investigated for its role in immune system regulation, cellular signaling, and thymic physiology.
Researchers continue to study Thymosin Alpha-1 for its interactions with both the innate and adaptive immune systems, including investigations involving dendritic cells, T lymphocytes, natural killer (NK) cells, antigen presentation, and cytokine signaling pathways. The peptide has become an important research tool for exploring mechanisms of immune regulation, host defense, inflammatory signaling, and cellular communication.
As an investigational peptide, Thymosin Alpha-1 supports laboratory research involving immunology, molecular biology, peptide pharmacology, receptor signaling, and structure-activity relationships. Ongoing studies continue to examine its biochemical characteristics and mechanisms of action in controlled experimental models.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
| Molecular Formula | C129H215N33O55 |
| Molecular Weight | 3,108.3 g/mol |
| CAS Number | 62304-98-7 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of THYMOSIN ALPHA-1 (Tα1) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide stability and biological integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Goldstein AL, Hannappel E. Thymosin Alpha 1: Biological Activities and Clinical Applications. Annals of the New York Academy of Sciences.
- Romani L. Immunity to Fungal Infections: Thymosin Alpha 1 as an Immunomodulatory Peptide. Nature Reviews Immunology.
- Garaci E, Pica F, Matteucci C, et al. Historical Review on Thymosin Alpha-1: From Discovery to Immunological Research. Expert Opinion on Biological Therapy.
- King R, Tuthill C. Immune Modulation by Thymosin Alpha-1. International Immunopharmacology.
Compare with related compounds
Other compounds researchers commonly browse alongside THYMOSIN ALPHA-1 (Tα1) in Immune & Antioxidant.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| THYMOSIN ALPHA-1 (Tα1) | 99% | 3,108.3 g/mol | 62304-98-7 |
| GLUTATHIONE (REDUCED L-GLUTATHIONE) | 99% | 307.32 g/mol | 70-18-8 |
| LL-37 (HUMAN CATHELICIDIN ANTIMICROBIAL PEPTIDE) | 99% | 4,493.27 g/mol | 154947-66-7 |
| KPV (LYS-PRO-VAL) | 99% | 358.43 g/mol | 67727-97-3 |
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