ARA-290 (CIBINETIDE)
Compound Overview
ARA-290, also known as Cibinetide, is a synthetic 11-amino acid peptide derived from the three-dimensional structure of the helix B region of erythropoietin (EPO). Unlike erythropoietin, ARA-290 was engineered to selectively activate tissue-protective signaling pathways without stimulating erythropoiesis (red blood cell production). This selectivity has made it an important investigational peptide for studying cellular repair mechanisms, inflammatory signaling, and neurobiology.
Researchers have investigated ARA-290 for its interactions with the innate repair receptor (IRR), a receptor complex comprising the erythropoietin receptor (EPOR) and CD131 (β-common receptor). Experimental studies have explored its role in regulating inflammatory signaling, neuronal physiology, tissue protection, and cellular homeostasis. As an investigational peptide, ARA-290 has become a valuable research tool in immunology, neuroscience, molecular pharmacology, and regenerative biology.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Chemical Name | Cibinetide (ARA-290) |
| Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (UEQLERALNSS) |
| Molecular Formula | C51H84N16O21 |
| Molecular Weight | 1,257.35 g/mol |
| CAS Number | 1208243-50-8 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of ARA-290 (CIBINETIDE) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide stability and structural integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Brines M, Patel NS, Villa P, et al. Nonerythropoietic, Tissue-Protective Peptides Derived from Erythropoietin. Proceedings of the National Academy of Sciences (PNAS).
- Brines M, Dunne AN, van Velzen M, et al. ARA-290, a Nonhematopoietic Peptide Engineered from Erythropoietin, Improves Symptoms in Small Fiber Neuropathy. Molecular Medicine.
- Brines M, Cerami A. The Receptor That Tames the Innate Immune Response. Molecular Medicine.
- Brines M, Cerami A. Discovering Erythropoietin's Extra-Hematopoietic Functions: Biology and Clinical Promise. Kidney International.
Compare with related compounds
Other compounds researchers commonly browse alongside ARA-290 (CIBINETIDE) in Neuro & Tissue Protection.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| ARA-290 (CIBINETIDE) | 99% | 1,257.35 g/mol | 1208243-50-8 |
| VIP (VASOACTIVE INTESTINAL PEPTIDE) | 99% | 3,326.86 g/mol | 40077-57-4 |
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