VIP (VASOACTIVE INTESTINAL PEPTIDE)
Compound Overview
Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino acid neuropeptide belonging to the secretin/glucagon peptide family. It is widely distributed throughout the central and peripheral nervous systems, gastrointestinal tract, respiratory system, pancreas, and immune tissues, where it functions as a neurotransmitter, neuromodulator, and regulatory peptide. Since its discovery in intestinal tissue, VIP has become an important research molecule for investigating neuroendocrine communication, immune regulation, and smooth muscle physiology.
Researchers have extensively investigated VIP for its interactions with the VPAC1 and VPAC2 G protein-coupled receptors, which activate cyclic adenosine monophosphate (cAMP)-dependent signaling pathways. Experimental studies continue to examine its role in neurobiology, endocrine physiology, gastrointestinal signaling, pulmonary biology, vascular function, and immunomodulatory pathways. Due to its broad distribution and diverse physiological effects, VIP remains an important investigational peptide in molecular pharmacology, receptor biology, and peptide signaling research.
As an investigational peptide, VIP supports laboratory research involving neurobiology, immunology, endocrinology, receptor pharmacology, and structure-activity relationship studies.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | HSDAVFTDNYTRLRKQMAVKKYLNSILN |
| Molecular Formula | C147H237N43O43S |
| Molecular Weight | 3,326.86 g/mol |
| CAS Number | 40077-57-4 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of VIP (VASOACTIVE INTESTINAL PEPTIDE) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Following reconstitution, avoid repeated freeze-thaw cycles, as these may reduce peptide stability and biological activity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Said SI, Mutt V. Polypeptide with Broad Biological Activity: Isolation from Small Intestine. Science.
- Dickson L, Finlayson K. VPAC and PAC Receptors: From Ligands to Function. Pharmacology & Therapeutics.
- Delgado M, Pozo D, Ganea D. The Significance of Vasoactive Intestinal Peptide in Immunomodulation. Pharmacological Reviews.
- Harmar AJ, Fahrenkrug J, Gozes I, et al. Pharmacology and Functions of Receptors for VIP and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP). Pharmacological Reviews.
Compare with related compounds
Other compounds researchers commonly browse alongside VIP (VASOACTIVE INTESTINAL PEPTIDE) in Neuro & Tissue Protection.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| VIP (VASOACTIVE INTESTINAL PEPTIDE) | 99% | 3,326.86 g/mol | 40077-57-4 |
| ARA-290 (CIBINETIDE) | 99% | 1,257.35 g/mol | 1208243-50-8 |
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