5-AMINO-1MQ
Compound Overview
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic small-molecule investigational compound that has gained attention as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). Unlike peptides, 5-Amino-1MQ is a low-molecular-weight organic molecule used extensively as a research tool for investigating cellular metabolism, nicotinamide metabolism, epigenetic regulation, and energy homeostasis.
Researchers have investigated 5-Amino-1MQ for its ability to inhibit NNMT, an enzyme involved in the methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor. Experimental studies have explored how modulation of NNMT influences cellular methylation potential, NAD+ metabolism, mitochondrial function, adipocyte biology, and metabolic signaling pathways. Due to the growing interest in NNMT biology, 5-Amino-1MQ has become a valuable investigational compound in metabolic research, molecular pharmacology, and epigenetics.
As an investigational small molecule, 5-Amino-1MQ supports laboratory research involving metabolism, enzyme pharmacology, molecular biology, and cellular signaling.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Pale Yellow Powder |
| Chemical Name | 5-Amino-1-methylquinolinium iodide |
| Molecular Formula | C10H11IN2 |
| Molecular Weight | 286.11 g/mol |
| CAS Number | 42464-96-0 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below in a tightly sealed container protected from moisture and light. |
| Research Grade | Laboratory Research Use Only. Note: 5-Amino-1MQ is a synthetic small molecule, not a peptide. |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of 5-AMINO-1MQ is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve compound stability. For extended laboratory storage, maintain at −20°C or below in a dry, light-protected environment. Protect the material from moisture, excessive heat, and prolonged exposure to light. Prepare solutions using appropriate laboratory-grade solvents and use sterile laboratory equipment together with established laboratory safety procedures. This product is intended exclusively for qualified research personnel conducting controlled laboratory investigations.
Selected Scientific Literature
- Kraus D, Yang Q, Kong D, et al. Nicotinamide N-Methyltransferase Knockdown Protects Against Diet-Induced Obesity. Nature.
- Neelakantan H, Brightwell CR, Graber TG, et al. Small Molecule Nicotinamide N-Methyltransferase Inhibitors Promote Metabolic Remodeling in Experimental Models. Biochemical Pharmacology.
- Aksoy S, Szumlanski CL, Weinshilboum RM. Human Nicotinamide N-Methyltransferase: Molecular Cloning and Biochemical Characterization. Journal of Biological Chemistry.
- Parsons RB, Aravindan S, Kadampeswaran A, et al. The Expression of Nicotinamide N-Methyltransferase Increases During Cellular Stress and Metabolic Adaptation. Biochemical Journal.
Compare with related compounds
Other compounds researchers commonly browse alongside 5-AMINO-1MQ in Metabolic & Weight Research.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| 5-AMINO-1MQ | 99% | 286.11 g/mol | 42464-96-0 |
| RETATRUTIDE | 99% | Approximately 4,731.33 g/mol | 2381089-83-2 |
| AOD-9604 | 99% | 1,815.08 g/mol | 221231-10-3 |
| CAGRILINTIDE | 99% | Approximately 4,183.8 g/mol | 1415456-99-3 |
| MAZDUTIDE | 99% | Approximately 4.5 kDa | Not Assigned |
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