KISSPEPTIN-10
Compound Overview
Kisspeptin-10 (KP-10) is a synthetic 10-amino acid peptide corresponding to the C-terminal active fragment of the endogenous kisspeptin protein encoded by the KISS1 gene. As the shortest biologically active fragment of the kisspeptin family, Kisspeptin-10 retains high affinity for the KISS1 receptor (KISS1R/GPR54) and has become an important investigational peptide in reproductive endocrinology, neurobiology, and receptor pharmacology research.
Researchers have extensively investigated Kisspeptin-10 for its interactions with KISS1R, a G protein-coupled receptor (GPCR) expressed within the hypothalamus and other tissues. Experimental studies have examined its role in regulating gonadotropin-releasing hormone (GnRH) neuronal signaling, neuroendocrine communication, reproductive physiology, intracellular calcium signaling, and endocrine feedback mechanisms. Due to its well-characterized receptor biology, Kisspeptin-10 serves as a valuable molecular probe for studying hypothalamic-pituitary-gonadal (HPG) axis regulation, GPCR signaling, and peptide-receptor interactions.
As an investigational peptide, Kisspeptin-10 supports laboratory research involving neuroendocrinology, reproductive biology, molecular pharmacology, peptide chemistry, and structure-activity relationship studies.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2) |
| Molecular Formula | C63H83N17O14 |
| Molecular Weight | 1,302.42 g/mol |
| CAS Number | 374675-21-5 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of KISSPEPTIN-10 is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Following reconstitution, avoid repeated freeze-thaw cycles, as these may reduce peptide stability and biological integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Kotani M, Detheux M, Vandenbogaerde A, et al. The Metastasis Suppressor Gene KISS1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. Journal of Biological Chemistry.
- Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 Gene as a Regulator of Puberty. New England Journal of Medicine.
- Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M. Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms. Physiological Reviews.
- Oakley AE, Clifton DK, Steiner RA. Kisspeptin Signaling in the Brain. Endocrine Reviews.
Compare with related compounds
Other compounds researchers commonly browse alongside KISSPEPTIN-10 in Reproductive & Hormonal.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| KISSPEPTIN-10 | 99% | 1,302.42 g/mol | 374675-21-5 |
| OXYTOCIN | 99% | 1,007.19 g/mol | 50-56-6 |
Need a Certificate of Analysis?
Request COAs, HPLC, or MS documentation for KISSPEPTIN-10.