IGF-1 LR3 (LONG R3 INSULIN-LIKE GROWTH FACTOR-1)
Compound Overview
IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a synthetic analog of human insulin-like growth factor-1 (IGF-1) engineered to provide enhanced metabolic stability and reduced affinity for insulin-like growth factor binding proteins (IGFBPs). The peptide incorporates a substitution of arginine for glutamic acid at position 3 and an N-terminal extension of 13 amino acids, resulting in a 83-amino acid peptide with a significantly prolonged biological half-life compared with native IGF-1.
IGF-1 LR3 selectively activates the insulin-like growth factor-1 receptor (IGF-1R), making it an important investigational peptide for studying cellular growth signaling, intracellular kinase pathways, receptor pharmacology, and peptide pharmacokinetics. Researchers continue to investigate its interactions with signaling cascades including PI3K/Akt, MAPK/ERK, and other pathways involved in cellular proliferation, differentiation, metabolism, and protein synthesis.
As an investigational peptide, IGF-1 LR3 supports laboratory research involving molecular biology, endocrinology, receptor signaling, peptide engineering, and structure-activity relationships in controlled experimental models.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | 83-amino acid recombinant IGF-1 analog with an N-terminal 13-amino acid extension and Arg3 substitution |
| Molecular Formula | C400H625N111O115S9 |
| Molecular Weight | 9,203.3 g/mol |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| CAS Number | 946870-92-4 |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of IGF-1 LR3 (LONG R3 INSULIN-LIKE GROWTH FACTOR-1) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide integrity and biological activity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Francis GL, Ross M, Ballard FJ, et al. Novel Recombinant Insulin-Like Growth Factor-I Analogs with Enhanced Biological Potency. Journal of Molecular Endocrinology.
- LeRoith D, Bondy C, Yakar S, Liu JL, Butler A. The Somatomedin Hypothesis: 2001. Endocrine Reviews.
- Jones JI, Clemmons DR. Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions. Endocrine Reviews.
- Pollak M. Insulin and Insulin-Like Growth Factor Signalling in Neoplasia. Nature Reviews Cancer.
Compare with related compounds
Other compounds researchers commonly browse alongside IGF-1 LR3 (LONG R3 INSULIN-LIKE GROWTH FACTOR-1) in Growth Hormone & Secretagogues.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| IGF-1 LR3 (LONG R3 INSULIN-LIKE GROWTH FACTOR-1) | 99% | 9,203.3 g/mol | 946870-92-4 |
| IPAMORELIN | 99% | 711.85 g/mol | 170851-70-4 |
| CJC-1295 & IPAMORELIN BLEND | 99% (Each Peptide) | — | Blend – Not Applicable |
| CJC-1295 (No DAC) | 99% | 3,364.0 g/mol | 86168-78-7 (Modified GRF (1-29)) |
| CJC-1295 (DAC) | 99% | 3,364.90 g/mol | 863288-34-0 |
Need a Certificate of Analysis?
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